Tellurium in PDB 1el7: Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Enzymatic activity of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
All present enzymatic activity of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate:
1.5.3.1;
Protein crystallography data
The structure of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate, PDB code: 1el7
was solved by
M.A.Wagner,
P.Trickey,
Z.-W.Chen,
F.S.Mathews,
M.S.Jorns,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
500.00 /
1.90
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
72.722,
69.504,
73.465,
90.00,
94.12,
90.00
|
R / Rfree (%)
|
17.5 /
21.3
|
Other elements in 1el7:
The structure of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate also contains other interesting chemical elements:
Tellurium Binding Sites:
The binding sites of Tellurium atom in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
(pdb code 1el7). This binding sites where shown within
5.0 Angstroms radius around Tellurium atom.
In total 6 binding sites of Tellurium where determined in the
Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate, PDB code: 1el7:
Jump to Tellurium binding site number:
1;
2;
3;
4;
5;
6;
Tellurium binding site 1 out
of 6 in 1el7
Go back to
Tellurium Binding Sites List in 1el7
Tellurium binding site 1 out
of 6 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Mono view
Stereo pair view
|
A full contact list of Tellurium with other atoms in the Te binding
site number 1 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Te801
b:24.8
occ:0.50
|
TE3
|
A:MTD801
|
0.0
|
24.8
|
0.5
|
C4
|
A:MTD801
|
1.9
|
19.9
|
0.5
|
TE3
|
A:MTD801
|
2.0
|
20.1
|
0.5
|
C4
|
A:MTD801
|
2.1
|
19.0
|
0.5
|
C2
|
A:MTD801
|
2.1
|
21.8
|
1.0
|
C1
|
A:MTD801
|
2.8
|
26.2
|
1.0
|
O6
|
A:MTD801
|
2.9
|
23.6
|
1.0
|
O
|
A:GLY344
|
3.1
|
13.9
|
1.0
|
C4
|
A:FAD400
|
3.3
|
14.3
|
1.0
|
C4X
|
A:FAD400
|
3.4
|
12.6
|
1.0
|
N3
|
A:FAD400
|
3.6
|
13.0
|
1.0
|
C10
|
A:FAD400
|
3.7
|
12.7
|
1.0
|
O4
|
A:FAD400
|
3.7
|
15.6
|
1.0
|
N5
|
A:FAD400
|
3.8
|
12.5
|
1.0
|
O5
|
A:MTD801
|
4.0
|
28.8
|
1.0
|
C2
|
A:FAD400
|
4.0
|
11.7
|
1.0
|
N1
|
A:FAD400
|
4.0
|
12.2
|
1.0
|
CA
|
A:HIS345
|
4.1
|
14.1
|
1.0
|
CE1
|
A:HIS269
|
4.1
|
16.9
|
1.0
|
CB
|
A:HIS345
|
4.1
|
13.2
|
1.0
|
C
|
A:GLY344
|
4.2
|
11.8
|
1.0
|
NZ
|
A:LYS348
|
4.4
|
10.5
|
1.0
|
N10
|
A:FAD400
|
4.5
|
13.0
|
1.0
|
ND1
|
A:HIS269
|
4.5
|
23.0
|
1.0
|
C5X
|
A:FAD400
|
4.6
|
14.5
|
1.0
|
N
|
A:HIS345
|
4.6
|
13.4
|
1.0
|
NH2
|
A:ARG52
|
4.7
|
18.0
|
1.0
|
NE2
|
A:HIS269
|
4.8
|
20.9
|
1.0
|
O2
|
A:FAD400
|
4.8
|
13.6
|
1.0
|
SD
|
A:MET245
|
4.9
|
22.3
|
1.0
|
C9A
|
A:FAD400
|
4.9
|
13.9
|
1.0
|
|
Tellurium binding site 2 out
of 6 in 1el7
Go back to
Tellurium Binding Sites List in 1el7
Tellurium binding site 2 out
of 6 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Mono view
Stereo pair view
|
A full contact list of Tellurium with other atoms in the Te binding
site number 2 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Te801
b:20.1
occ:0.50
|
TE3
|
A:MTD801
|
0.0
|
20.1
|
0.5
|
TE3
|
A:MTD801
|
2.0
|
24.8
|
0.5
|
C2
|
A:MTD801
|
2.1
|
21.8
|
1.0
|
C4
|
A:MTD801
|
2.1
|
19.9
|
0.5
|
C4
|
A:MTD801
|
2.4
|
19.0
|
0.5
|
C1
|
A:MTD801
|
2.9
|
26.2
|
1.0
|
SD
|
A:MET245
|
3.4
|
22.3
|
1.0
|
O6
|
A:MTD801
|
3.5
|
23.6
|
1.0
|
CE1
|
A:HIS269
|
3.6
|
16.9
|
1.0
|
O5
|
A:MTD801
|
3.6
|
28.8
|
1.0
|
ND1
|
A:HIS269
|
3.6
|
23.0
|
1.0
|
CE
|
A:MET245
|
3.8
|
22.7
|
1.0
|
NE2
|
A:HIS269
|
3.8
|
20.9
|
1.0
|
CD1
|
A:TYR254
|
3.9
|
17.8
|
1.0
|
CG
|
A:HIS269
|
3.9
|
20.8
|
1.0
|
CG
|
A:TYR254
|
3.9
|
16.3
|
1.0
|
CD2
|
A:HIS269
|
4.1
|
19.3
|
1.0
|
CB
|
A:TYR254
|
4.1
|
14.2
|
1.0
|
CG
|
A:MET245
|
4.3
|
15.9
|
1.0
|
O
|
A:GLY344
|
4.4
|
13.9
|
1.0
|
CE1
|
A:TYR254
|
4.6
|
13.6
|
1.0
|
CD2
|
A:TYR254
|
4.6
|
14.5
|
1.0
|
CB
|
A:HIS269
|
4.7
|
17.1
|
1.0
|
NH2
|
A:ARG52
|
4.7
|
18.0
|
1.0
|
O4
|
A:FAD400
|
4.9
|
15.6
|
1.0
|
C4
|
A:FAD400
|
4.9
|
14.3
|
1.0
|
OH
|
A:TYR317
|
5.0
|
14.2
|
1.0
|
|
Tellurium binding site 3 out
of 6 in 1el7
Go back to
Tellurium Binding Sites List in 1el7
Tellurium binding site 3 out
of 6 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Mono view
Stereo pair view
|
A full contact list of Tellurium with other atoms in the Te binding
site number 3 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Te805
b:24.7
occ:0.21
|
SG
|
A:CYS262
|
3.0
|
40.9
|
1.0
|
CA
|
A:CYS262
|
3.7
|
23.7
|
1.0
|
CB
|
A:CYS262
|
3.8
|
31.5
|
1.0
|
O
|
A:HOH1163
|
4.1
|
33.4
|
1.0
|
O
|
A:GLY261
|
4.3
|
25.1
|
1.0
|
N
|
A:CYS262
|
4.4
|
23.5
|
1.0
|
NZ
|
A:LYS310
|
4.4
|
28.2
|
1.0
|
CE
|
A:LYS310
|
4.5
|
26.5
|
1.0
|
C
|
A:GLY261
|
4.6
|
22.7
|
1.0
|
O
|
A:HOH864
|
4.8
|
23.3
|
1.0
|
C
|
A:CYS262
|
4.8
|
23.2
|
1.0
|
O
|
A:CYS262
|
5.0
|
21.5
|
1.0
|
O
|
A:GLY260
|
5.0
|
17.3
|
1.0
|
|
Tellurium binding site 4 out
of 6 in 1el7
Go back to
Tellurium Binding Sites List in 1el7
Tellurium binding site 4 out
of 6 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Mono view
Stereo pair view
|
A full contact list of Tellurium with other atoms in the Te binding
site number 4 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Te811
b:24.2
occ:0.50
|
TE3
|
B:MTD811
|
0.0
|
24.2
|
0.5
|
C4
|
B:MTD811
|
2.0
|
20.2
|
0.5
|
C4
|
B:MTD811
|
2.0
|
19.5
|
0.5
|
C2
|
B:MTD811
|
2.1
|
21.2
|
1.0
|
TE3
|
B:MTD811
|
2.1
|
22.8
|
0.5
|
C1
|
B:MTD811
|
2.9
|
25.6
|
1.0
|
O6
|
B:MTD811
|
2.9
|
21.9
|
1.0
|
O
|
B:GLY344
|
3.0
|
14.4
|
1.0
|
C4
|
B:FAD400
|
3.4
|
13.6
|
1.0
|
C4X
|
B:FAD400
|
3.4
|
14.1
|
1.0
|
N3
|
B:FAD400
|
3.6
|
13.5
|
1.0
|
C10
|
B:FAD400
|
3.7
|
14.5
|
1.0
|
O4
|
B:FAD400
|
3.8
|
14.1
|
1.0
|
N5
|
B:FAD400
|
3.9
|
15.0
|
1.0
|
C2
|
B:FAD400
|
3.9
|
14.2
|
1.0
|
N1
|
B:FAD400
|
4.0
|
12.3
|
1.0
|
CA
|
B:HIS345
|
4.0
|
12.7
|
1.0
|
O5
|
B:MTD811
|
4.0
|
30.4
|
1.0
|
CB
|
B:HIS345
|
4.0
|
11.7
|
1.0
|
CE1
|
B:HIS269
|
4.1
|
16.8
|
1.0
|
C
|
B:GLY344
|
4.1
|
11.8
|
1.0
|
NZ
|
B:LYS348
|
4.4
|
12.9
|
1.0
|
N10
|
B:FAD400
|
4.5
|
13.9
|
1.0
|
ND1
|
B:HIS269
|
4.5
|
17.7
|
1.0
|
N
|
B:HIS345
|
4.5
|
14.8
|
1.0
|
C5X
|
B:FAD400
|
4.6
|
14.6
|
1.0
|
NH2
|
B:ARG52
|
4.6
|
18.3
|
1.0
|
O2
|
B:FAD400
|
4.7
|
14.3
|
1.0
|
NE2
|
B:HIS269
|
4.7
|
14.4
|
1.0
|
SD
|
B:MET245
|
4.9
|
21.0
|
1.0
|
C9A
|
B:FAD400
|
4.9
|
14.9
|
1.0
|
|
Tellurium binding site 5 out
of 6 in 1el7
Go back to
Tellurium Binding Sites List in 1el7
Tellurium binding site 5 out
of 6 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Mono view
Stereo pair view
|
A full contact list of Tellurium with other atoms in the Te binding
site number 5 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Te811
b:22.8
occ:0.50
|
TE3
|
B:MTD811
|
0.0
|
22.8
|
0.5
|
C2
|
B:MTD811
|
2.1
|
21.2
|
1.0
|
C4
|
B:MTD811
|
2.1
|
20.2
|
0.5
|
TE3
|
B:MTD811
|
2.1
|
24.2
|
0.5
|
C4
|
B:MTD811
|
2.3
|
19.5
|
0.5
|
C1
|
B:MTD811
|
2.9
|
25.6
|
1.0
|
SD
|
B:MET245
|
3.4
|
21.0
|
1.0
|
O5
|
B:MTD811
|
3.5
|
30.4
|
1.0
|
CE1
|
B:HIS269
|
3.5
|
16.8
|
1.0
|
ND1
|
B:HIS269
|
3.5
|
17.7
|
1.0
|
O6
|
B:MTD811
|
3.6
|
21.9
|
1.0
|
NE2
|
B:HIS269
|
3.8
|
14.4
|
1.0
|
CE
|
B:MET245
|
3.8
|
23.3
|
1.0
|
CD1
|
B:TYR254
|
3.9
|
15.7
|
1.0
|
CG
|
B:HIS269
|
3.9
|
16.5
|
1.0
|
CG
|
B:TYR254
|
3.9
|
16.3
|
1.0
|
CD2
|
B:HIS269
|
4.1
|
16.0
|
1.0
|
CB
|
B:TYR254
|
4.1
|
14.0
|
1.0
|
CG
|
B:MET245
|
4.4
|
17.6
|
1.0
|
O
|
B:GLY344
|
4.4
|
14.4
|
1.0
|
CE1
|
B:TYR254
|
4.5
|
19.0
|
1.0
|
CD2
|
B:TYR254
|
4.6
|
16.2
|
1.0
|
CB
|
B:HIS269
|
4.6
|
12.2
|
1.0
|
NH2
|
B:ARG52
|
4.7
|
18.3
|
1.0
|
OH
|
B:TYR317
|
4.9
|
14.9
|
1.0
|
C4
|
B:FAD400
|
5.0
|
13.6
|
1.0
|
O4
|
B:FAD400
|
5.0
|
14.1
|
1.0
|
|
Tellurium binding site 6 out
of 6 in 1el7
Go back to
Tellurium Binding Sites List in 1el7
Tellurium binding site 6 out
of 6 in the Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate
Mono view
Stereo pair view
|
A full contact list of Tellurium with other atoms in the Te binding
site number 6 of Complex of Monomeric Sarcosine Oxidase with the Inhibitor [Methytelluro]Acetate within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Te815
b:25.5
occ:0.22
|
SG
|
B:CYS262
|
2.9
|
32.9
|
1.0
|
CA
|
B:CYS262
|
3.7
|
21.9
|
1.0
|
CB
|
B:CYS262
|
3.8
|
28.6
|
1.0
|
O
|
B:HOH1203
|
4.1
|
44.9
|
1.0
|
O
|
B:GLY261
|
4.2
|
20.7
|
1.0
|
N
|
B:CYS262
|
4.3
|
20.5
|
1.0
|
NZ
|
B:LYS310
|
4.5
|
23.0
|
1.0
|
C
|
B:GLY261
|
4.5
|
21.9
|
1.0
|
CE
|
B:LYS310
|
4.5
|
22.3
|
1.0
|
C
|
B:CYS262
|
4.8
|
19.2
|
1.0
|
O
|
B:HOH881
|
4.8
|
24.6
|
1.0
|
O
|
B:GLY260
|
4.8
|
17.2
|
1.0
|
O
|
B:HOH1047
|
4.9
|
43.2
|
1.0
|
O
|
B:CYS262
|
5.0
|
18.4
|
1.0
|
|
Reference:
M.A.Wagner,
P.Trickey,
Z.W.Chen,
F.S.Mathews,
M.S.Jorns.
Monomeric Sarcosine Oxidase: 1. Flavin Reactivity and Active Site Binding Determinants. Biochemistry V. 39 8813 2000.
ISSN: ISSN 0006-2960
PubMed: 10913292
DOI: 10.1021/BI000349Z
Page generated: Fri Oct 11 08:57:50 2024
|