Tellurium in PDB 7zsn: Human Purine Nucleoside Phosphorylase in Complex with Js-379

All present enzymatic activity of Human Purine Nucleoside Phosphorylase in Complex with Js-379:
2.4.2.1;

The structure of Human Purine Nucleoside Phosphorylase in Complex with Js-379, PDB code: 7zsn was solved by S.Djukic, P.Pachl, P.Rezacova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.01 / 2.36
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	141.72, 141.72, 162.44, 90, 90, 120
R / Rfree (%)	22 / 25.9

The structure of Human Purine Nucleoside Phosphorylase in Complex with Js-379 also contains other interesting chemical elements:

Tungsten	(W)	18 atoms
Bromine	(Br)	1 atom

The binding sites of Tellurium atom in the Human Purine Nucleoside Phosphorylase in Complex with Js-379 (pdb code 7zsn). This binding sites where shown within 5.0 Angstroms radius around Tellurium atom.
In total 3 binding sites of Tellurium where determined in the Human Purine Nucleoside Phosphorylase in Complex with Js-379, PDB code: 7zsn:
Jump to Tellurium binding site number: 1; 2; 3;

Tellurium binding site 1 out of 3 in the Human Purine Nucleoside Phosphorylase in Complex with Js-379


Mono view


Stereo pair view

A full contact list of Tellurium with other atoms in the Te binding site number 1 of Human Purine Nucleoside Phosphorylase in Complex with Js-379 within 5.0Å range: probe atom residue distance (Å) B Occ A:Te302 b:73.5 occ:0.30 TE1 A:TEW302 0.0 73.5 0.3 O13 A:TEW302 1.9 78.4 0.3 O2 A:TEW302 1.9 76.2 0.3 O12 A:TEW302 1.9 71.4 0.3 O7 A:TEW302 1.9 78.2 0.3 O11 A:TEW302 2.0 75.2 0.3 O1 A:TEW302 2.0 78.8 0.3 W3 A:TEW302 3.2 84.6 0.3 W4 A:TEW302 3.3 71.4 0.3 O4 A:TEW302 3.3 83.3 0.3 O10 A:TEW302 3.3 77.4 0.3 W2 A:TEW302 3.4 79.1 0.3 W6 A:TEW302 3.4 80.4 0.3 W5 A:TEW302 3.4 69.4 0.3 O14 A:TEW302 3.4 78.6 0.3 W1 A:TEW302 3.4 83.7 0.3 O17 A:TEW302 3.5 72.6 0.3 O20 A:TEW302 3.5 67.2 0.3 O3 A:TEW302 3.6 79.2 0.3 O15 A:TEW302 4.5 85.3 0.3 O16 A:TEW302 4.5 75.6 0.3 O19 A:TEW302 4.5 74.0 0.3 O18 A:TEW302 4.6 75.0 0.3 O22 A:TEW302 4.6 55.7 0.3 O8 A:TEW302 4.6 81.2 0.3 O23 A:TEW302 4.6 63.2 0.3 O31 A:TEW302 4.6 75.4 0.3 O9 A:TEW302 4.7 82.3 0.3 O5 A:TEW302 4.7 86.3 0.3 O6 A:TEW302 4.7 77.1 0.3 O21 A:TEW302 4.7 62.6 0.3

Tellurium binding site 2 out of 3 in the Human Purine Nucleoside Phosphorylase in Complex with Js-379


Mono view


Stereo pair view

A full contact list of Tellurium with other atoms in the Te binding site number 2 of Human Purine Nucleoside Phosphorylase in Complex with Js-379 within 5.0Å range: probe atom residue distance (Å) B Occ A:Te303 b:114.0 occ:0.30 TE1 A:TEW303 0.0 114.0 0.3 O11 A:TEW303 1.9 119.5 0.3 O2 A:TEW303 1.9 115.5 0.3 O12 A:TEW303 1.9 119.9 0.3 O7 A:TEW303 1.9 121.9 0.3 O13 A:TEW303 1.9 116.1 0.3 O1 A:TEW303 1.9 118.7 0.3 W2 A:TEW303 3.3 130.7 0.3 W6 A:TEW303 3.3 119.8 0.3 W1 A:TEW303 3.3 107.9 0.3 W4 A:TEW303 3.3 126.5 0.3 W5 A:TEW303 3.3 122.6 0.3 O10 A:TEW303 3.3 124.8 0.3 W3 A:TEW303 3.3 120.1 0.3 O20 A:TEW303 3.4 122.3 0.3 O3 A:TEW303 3.4 119.0 0.3 O4 A:TEW303 3.4 115.5 0.3 O14 A:TEW303 3.5 120.1 0.3 O17 A:TEW303 3.5 121.3 0.3 O8 A:TEW303 4.5 119.9 0.3 O5 A:TEW303 4.5 115.9 0.3 O31 A:TEW303 4.5 117.9 0.3 O23 A:TEW303 4.5 111.2 0.3 O19 A:TEW303 4.5 121.0 0.3 O9 A:TEW303 4.5 122.4 0.3 O22 A:TEW303 4.6 119.6 0.3 O6 A:TEW303 4.6 111.5 0.3 O15 A:TEW303 4.6 113.0 0.3 O18 A:TEW303 4.6 120.0 0.3 O16 A:TEW303 4.6 118.9 0.3 O21 A:TEW303 4.6 121.2 0.3

Tellurium binding site 3 out of 3 in the Human Purine Nucleoside Phosphorylase in Complex with Js-379


Mono view


Stereo pair view

A full contact list of Tellurium with other atoms in the Te binding site number 3 of Human Purine Nucleoside Phosphorylase in Complex with Js-379 within 5.0Å range: probe atom residue distance (Å) B Occ A:Te304 b:147.4 occ:0.33 TE1 A:TEW304 0.0 147.4 0.3 O2 A:TEW304 1.9 127.0 0.3 O13 A:TEW304 1.9 131.9 0.3 O11 A:TEW304 1.9 145.7 0.3 O7 A:TEW304 1.9 137.9 0.3 O1 A:TEW304 1.9 132.3 0.3 O12 A:TEW304 1.9 142.6 0.3 W6 A:TEW304 3.2 167.4 0.3 W1 A:TEW304 3.2 137.5 0.3 W2 A:TEW304 3.2 132.7 0.3 W3 A:TEW304 3.3 103.0 0.3 W5 A:TEW304 3.3 161.5 0.3 W4 A:TEW304 3.3 138.8 0.3 O10 A:TEW304 3.3 134.7 0.3 O3 A:TEW304 3.4 133.2 0.3 O20 A:TEW304 3.4 147.5 0.3 O14 A:TEW304 3.4 135.1 0.3 O4 A:TEW304 3.4 126.6 0.3 O17 A:TEW304 3.4 143.1 0.3 CE A:LYS95 4.2 77.2 1.0 NZ A:LYS95 4.2 83.8 1.0 O31 A:TEW304 4.4 156.7 0.3 O23 A:TEW304 4.4 148.2 0.3 O5 A:TEW304 4.4 126.7 0.3 O8 A:TEW304 4.4 127.5 0.3 O15 A:TEW304 4.5 119.5 0.3 O22 A:TEW304 4.5 147.8 0.3 O19 A:TEW304 4.5 135.5 0.3 O9 A:TEW304 4.5 131.9 0.3 O6 A:TEW304 4.5 129.2 0.3 O16 A:TEW304 4.5 118.7 0.3 O18 A:TEW304 4.6 141.0 0.3 O21 A:TEW304 4.6 152.1 0.3

J.Skacel, S.Djukic. Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Pnp Inhibitors To Be Published.